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   Internationale Nachwuchsforschergruppen

Local Immune Control of Cancer within the Tumour Microenvironment

Technische Universität München


Internationale Nachwuchsforschergruppe in den Lebenswissenschaften


Leitung: Dr. Jan Philipp Böttcher


Kontakt: j.boettcher@tum.de



Projektdauer: 5 Jahre


Angliederung an das Programm des Elitenetzwerks Bayern:
Internationales Doktorandenkolleg "i-Target: Immunotargeting of cancer"


Cancer encompasses a plethora of neoplastic diseases that severely affects - and often threatens - the life of a many people around the globe. According to current estimates by the World Health organisation (WHO), more than 32 million people are currently living with cancer, and almost every second person alive today will be diagnosed with cancer during his or her lifetime. While the research and the development of cancer therapies has led to a significantly improvement of survival for many types of cancer, half of the people diagnosed with cancer still succumb to their disease within ten years.

Recent developments in cancer research have established that the changes that occur in cancer cells during their neoplastic transformation and the development of cancer can be detected by the immune system. Immune cells frequently infiltrate tumour tissue, where they interact with cancer cells and associated stromal cells within the tumour microenvironment. Depending on the cell type and their functional state, immune cells can either support cancer progression or fight cancer growth and even mediate tumour rejection. Consequently, cancer cells have often developed mechanism to evade detection and destruction by the immune system in order to grow. Although many underlying processes remain only incompletely understood, the field of Immune-Oncology has led to the development of promising immunotherapies that target cells of the immune system to fight cancer, including Immune Checkpoint Blockade and T cell therapy.

The group led by Dr. Jan Böttcher uses modern imaging techniques and bioinformatic analyses of cancer patient data to decipher the mechanisms that control local anti-tumour immunity within tumours and their surrounding microenvironment. Major aims of the group are to identify and understand molecular mechanisms that could be targeted therapeutically to treat cancer, including the pathways that regulate the access of innate and adaptive immune cells into tumours, the initiation and modulation of immune cell phenotypes and the local communication between immune cells within tumour tissue. Understanding these processes is key for the development of novel cancer immunotherapies.


Kontakt
Dr. Jan Philipp Böttcher
Institute of Molecular Immunology
Klinikum rechts der Isar
Technische Universität München
Ismaningerstr. 22
81675 München
Tel.: 089 4140 4453

Gefördert durch:
  • Bayerisches Staatsministerium für Wissenschaft und Kunst
  • Elitenetzwerk Bayern:
  • ab 1. Mai 2018